GLP‑1 receptor agonists (GLP‑1RAs) like Ozempic® and Mounjaro® are becoming increasingly popular for weight and blood sugar management—but they can come with nutritional downsides that are often overlooked. Here’s why having an Accredited Practising Dietitian (APD) as part of the care team is vital from the start.
Credits: Investigating nutrient intake during use of glucagon-like peptide-1 receptor agonist: a cross-sectional study, Johnson, B.,Frontiers in Nutrition, 12, 1566498
1. These medications can lead to significant nutrient shortfalls
A study of 69 people on GLP‑1RAs found that many were falling short on a long list of nutrients—including vitamin D, calcium, iron, magnesium, potassium, vitamins A, C, E, K, choline, fibre and protein—when compared to recommended dietary intakes (DRIs).
Worryingly, nearly half weren’t receiving any nutritional guidance, and only 1 in 5 had seen an Accredited Dietitian.
2. Micronutrient deficiencies and muscle loss are common
Longer-term use of GLP‑1RAs is associated with vitamin D deficiency (~13%), low B vitamins (2–4%), nutritional anaemia, and muscle loss. Some clinical data suggest that 20–60% of total weight lost may come from lean muscle—not fat—especially in the absence of nutrition and exercise support.
3. Accredited Dietitians pick up on problems earlier
People who had regular check-ins with an APD had higher rates of diagnosed deficiencies (29.8% vs 21.8%). This doesn’t mean they were worse off—it means the problems were picked up earlier and could be treated before they caused more serious health issues like fatigue, low immunity, or bone loss.
4. Guidelines back it up: Nutrition therapy is essential
Leading nutrition organisations, including the Academy of Nutrition & Dietetics and international obesity care guidelines, recommend dietitian involvement in GLP‑1RA care. These medications affect the body much like bariatric surgery does—so the same level of nutritional care is warranted.
Ensuring enough protein, vitamins, and resistance exercise is key to preventing muscle and bone loss, which can otherwise sneak up during rapid weight changes.
5. What can Accredited Dietitians actually do?
APDs aren’t just about meal plans—they personalise care to make sure your body stays healthy while losing weight:
- Set realistic macronutrient goals
- Spot and treat nutrient gaps early—through food, and if needed, supplements
- Adjust meal timing and content to help with nausea, fullness, or low appetite
- Recommend resistance training to protect muscle mass and metabolism
A Dietitian-Led Care Pathway
Stage | Role of the Accredited Dietitian |
Before starting | Nutrition assessment to check for any existing deficiencies (often common in obesity) |
Early follow-up | Review food intake and tailor a plan to work around appetite changes |
Mid-term (6–12 mo) | Review bloods (vitamin D, iron, B12), adjust supplements and support muscle maintenance |
Ongoing care | Build long-term eating strategies, support healthy habits, and link in with exercise professionals |
Why This Model Matters
- Safety First: Catching and fixing deficiencies early helps avoid fatigue, anaemia, weak bones, or nerve issues
- Better Results: Keeping protein and muscle mass up supports energy, satiety, and long-term weight management
- Smart Care: Dietitian support can reduce long-term healthcare costs by preventing avoidable side effects
In Summary
GLP‑1RAs can be a powerful tool for weight and metabolic health—but they’re not without risks. Nutrient deficiencies and muscle loss are common, especially when people go it alone.
By bringing an Accredited Practising Dietitian into your care team early, you get expert guidance to support your body through each stage of the journey—keeping you strong, nourished, and on track for lasting success.
Disclaimer: The information provided in this blog is sourced from research articles and reputable websites. However, as each individual’s body and health needs are unique, it is essential to consult with your doctor, dietitian, or healthcare provider for personalised advice and plans tailored specifically to your condition.
Acknowledgement: I would like to extend my heartfelt gratitude to our CEO, Purva Gulyani – Accredited Practising Dietitian, for providing me with the opportunity to contribute to this blog. Your valuable feedback, along with your time spent proofreading and editing, has greatly enhanced the quality of this work. Your guidance and support are truly appreciated.
References:
- Despain, D., & Hoffman, B. L. (2024). Optimizing nutrition, diet, and lifestyle communication in GLP-1 medication therapy for weight management: A qualitative research study with registered dietitians. Obesity pillars, 12, 100143. https://doi.org/10.1016/j.obpill.2024.100143
- Johnson, B., Milstead, M., Thomas, O., McGlasson, T., Green, L., Kreider, R., & Jones, R. (2025). Investigating nutrient intake during use of glucagon-like peptide-1 receptor agonist: A cross-sectional study. Frontiers in Nutrition, 12, 1566498
- Neeland, I. J., Linge, J., & Birkenfeld, A. L. (2024). Changes in lean body mass with glucagon-like peptide-1-based therapies and mitigation strategies. Diabetes, obesity & metabolism, 26 Suppl 4, 16–27. https://doi.org/10.1111/dom.15728
- https://www.thetimes.com/life-style/health-fitness/article/the-weight-loss-drugs-guide-how-to-temper-the-side-effects-6tbzs657t?utm_source=chatgpt.com®ion=global